I’ve seen this throughout the web, but thought I would add it to my own archives after it finally solved my problem.
A few months after upgrading to Windows 10, my Chrome browser started rendering fonts terribly. It was fuzzy and hard to read. I have no idea why it happened long after Windows 10, but it was very annoying and I lived with it for about 3 months.
What finally fixed it for me was opening a new chrome tab, going to chrome://flags, and disabled DirectWrite. After I relaunched the browser everything was back to normal!